How does MK-677 increase growth hormone production?
Ibutamoren, also known as MK-677, is a growth hormone secretagogue. This means it stimulates the release of growth hormone (GH) and insulin-like growth factor 1 (IGF-1) from the pituitary gland and the liver, respectively.
Ibutamoren works by mimicking the action of ghrelin, a hormone produced by the stomach that stimulates the release of GH and IGF-1. Ghrelin binds to growth hormone secretagogue receptors (GHS-R) in the pituitary gland and hypothalamus, which leads to an increase in the production and release of GH and IGF-1.
Ibutamoren also increases the release of other hormones that are involved in the regulation of metabolism, such as glucose and insulin. This can lead to an increase in muscle mass, strength, and bone density, as well as a decrease in body fat.
In addition, Ibutamoren has been found to have a positive effect on sleep, which may also contribute to its ability to increase GH and IGF-1 levels.
It has been studied in both animal models and human clinical trials, and has shown promise as a potential treatment for a variety of conditions, including growth hormone deficiency, muscle wasting, and osteoporosis. However, further research is needed to fully understand its potential benefits and risks. Additionally, the majority of the studies conducted on the substance are sponsored by the company that developed the compound.
One study found that daily oral administration of MK-677 for 12 weeks increased GH and IGF-1 levels in healthy elderly men and women. The study also found that the treatment resulted in an increase in lean body mass and a decrease in fat mass, as well as improvements in bone density. Another study found that MK-677 was able to increase GH and IGF-1 levels in adults with growth hormone deficiency (GHD). The treatment also led to an increase in muscle mass and strength, and a decrease in body fat.
It is important to note that while MK-677 is a growth hormone secretagogue, it is not a growth hormone, and its effects are different than those of exogenous growth hormone.
Overall, Ibutamoren is a synthetic compound that mimics the action of ghrelin by binding to GHS-R receptors in the pituitary gland and hypothalamus, which leads to an increase in the production and release of GH and IGF-1. This can lead to an increase in muscle mass, strength, and bone density, as well as a decrease in body fat.
Smith RG, Thorner MO (28 January 2000). Human Growth Hormone: Research and Clinical Practice. Springer Science & Business Media. pp. 45–. ISBN 978-1-59259-015-5.
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